Chronic Cyclosporine Nephrotoxicity: New Insights and Preventive Strategies

Cyclosporine nephrotoxicity.

After more than 20 years of cyclosporine use its nephrotoxicity remains a significant clinical problem. Cyclosporine-induced renal injury has been described in solid organs recipients and in patients treated for autoimmune diseases. It is manifested in 2 distinct and well characterized forms, acute nephrotoxicity and chronic nephrotoxicity. This communication reviews the current literature anal...

insights into the possible mechanism of cyclosporine-induced chronic nephrotoxicity; arteriolopathy

Insights into the Possible Mechanism of Cyclosporine-Induced Chronic Nephrotoxicity; Arteriolopathy

I read with great interest the recent contribution by Uz et al. (1) that demonstrated the protective effects of erdosteine on cyclosporine (CsA)-induced chronic nephp-rotoxicity in rats. The authors however, did not suggest the possible mechanism of nephrotoxicity or the recent reports concerning the action of antioxidants on neph-rotoxicity. I would like to add some considerations on the notew...

New insights into the pathophysiology of cyclosporine nephrotoxicity: a role of aldosterone.

Cyclosporine A (CsA), a calcineurin inhibitor, has improved allograft survival in solid organ transplantation and has been increasingly applied in the management of autoimmune diseases. While marked progress has been made in patient and allograft survival rates, clinical use of CsA is often limited by its nephrotoxic effect, which can be presented as two distinct and well-characterized forms: a...

New insights into Pathophysiology of Cyclosporine Nephrotoxicity: A role of aldosterone

Cyclosporine A, a calcineurin inhibitor, has improved allograft survival in solid organ transplantation and has been increasingly applied in the management of autoimmune diseases. While marked progress has been made in patient and allograft survival rates, clinical use of CsA is often limited by its nephrotoxic effect, which can be presented as two distinct and well characterized forms: acute a...